The commonest causes of upper digestive symptoms include poor dietary habits, and poor lifestyle which should be corrected. Millions of Americans take prescription or over-the-counter (OTC) drugs to treat upper digestive symptoms. These drugs include H-2 receptor antagonists (e.g. Tagamet, Pepcid, Zantac, Axid and others) or proton pump inhibitor drugs e.g. Prilosec, Nexium etc. These drugs are available often OTC and they all work by reducing the secretion of acid by the stomach. Drugs like Prilosec have become particularly popular because they work generally by completely abolishing stomach acid. Many scientists have expressed concern about the long term use of potent drugs that diminish the presence of acid in the stomach in a potent manner. These drugs that reduce acid secretion in a potent manner are highly effective and reducing symptoms of heartburn, but they have not been shown to be completely effective in managing functional disorders of the digestive tract. While the drive to use acid-suppressing drugs is symptom relief, the relief of symptoms alone may permit the individual to engage in the adverse lifestyle that caused the functional digestive upset in the first place.

Recent research has shown that certain antioxidants can alter acid secretion by blocking stomach pumps (a proton pump inhibitor effect). In contrast to proton pump inhibitor drugs, such as Prilosec, these antioxidants have a much milder effect on acid secretion and do not completely abolish stomach acid, resulting in a potentially healthier circumstance where gastric acid can exert its important functions in the digestive process. A lot of inflammation in the upper digestive tract is caused by oxidative stress and infection with the bacterium Helicobacter pylori causes free radical damage which may result in inflammation of the lining of the digestive tract, peptic ulcer and precancerous changes in the lining of certain parts of the upper digestive tract, particularly the lower Esophagus and regions of the stomach. Heartburn Naturally contains powerful antioxidants including ellagic acid, green tea extract and turmeric. Ellagic acid has been shown in laboratory experiments to suppress acid secretion by the stomach with the mechanism action similar to that of proton pumping inhibitor drugs.