A European, pharmaceutical grade SAM-e found to promote healthy mood, liver and joint function. A powerful, natural nutrient, S-adenosyl methionine (SAM-e) promotes healthy mood, liver and joint function. Numerous studies going back two decades, including a 2002 study sponsored by the U.S. Department of Health and Human Resources (HHS), show that SAM-e is quite safe and effective for promoting healthy mood and liver function, as well as joint function. SAM-e supplementation benefits aging people, as they are prone to experience joint discomfort and immobilization. NSI SAM-e is pharmaceutical grade, full potency, and stabilized. SAM-e supplements contain amounts of both the active SS form and the inactive RS form. NSI SAM-e undergoes a natural process of microbiological fermentation, and is then specially processed without solvents. This process ensures an active SS level of 68-80%, the highest concentration available.
SAM-e is believed to raise the levels of specific neurotransmitters, especially that of dopamine, which is important for mood regulation. Higher SAM-e levels in the brain are associated with successful improvement of mood. While not as powerful as antidepressants, a study published in the Journal of Psychiatric Research showed that SAM-e takes effect within one week, quicker than that of drug antidepressants, as well as St. John's Wort. And unlike antidepressants, SAM-e does not lead to such typical side effects as weight gain, headaches, and sexual dysfunction.
Studies published in the American Journal of Medicine show that SAM-e may benefit joint health. Studies have shown that SAM-e may be effective for improving joint function and reducing pain. SAM-e boosts natural antioxidant levels, and may provide benefits for health concerns including liver health, muscle health and homocysteine levels. In the liver, SAM-e has been shown to improve the flow of bile and replenish important antioxidants. A double-blind study concerning muscle health published in the Scandinavian Journal of Rheumatology showed that 800 mg daily of SAM-e supplementation for six weeks resulted in reduced pain, fatigue, and stiffness, and improved mood. SAM-e may also lower homocysteine levels, high levels of which have been proven to cause neurological and cardiovascular problems. Additionally, SAM-e is critical for transmethylation, the process that enables the body to repair cells and detoxify, and also affects the activation, synthesis and metabolism of various biological molecules.
The typical SAM-e dosage is 400-800 mg daily for promoting a healthy mood, liver and joints. It must be consumed as a tablet that is enteric-coated and is in the stabilized and standardized form. As SAM-e is 50% elemental, a product must provide 800 mg gross to equal 400 mg elemental, thereby making it beneficial. NSI SAM-e 200 mg (from 400 mg gross) offers 60 enteric-coated tablets. Additionally, NSI provides a SAM-e 400 mg (from 800 mg gross) supplement offering 30 enteric-coated tablets. NSI's SAM-e is pharmaceutical grade from Europe. Beware of some SAM-e products that are of inferior quality.
